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KBT hjälper vid terapiresistent depression

6 augusti 2013 (21:31) | depression, KBT | av: Ludmilla

En studie har testat att lägga till KBT för patienter som har fått antidepressiva under minst ett år men inte blivit förbättrade. Resultaten visar att KBT gör att behandlingsresultaten förbättras avsevärt.

A total of 469 adults (average age 49.6 years, 72% female and 44% in paid employment) with treatment resistant depression (meeting ICD-10 criteria for depression, treated with adequate dose of antidepressants for ≥6 weeks but still with Beck depression inventory (BDI) score ≥14). For more than half of the participants (59%) the current depression episode had lasted 2 years or longer, and 70% had taken their antidepressant for over a year. People with bipolar disorder, psychotic disorder, or major alcohol or substance abuse problems were excluded, as were pregnant women, those unable to complete study questionnaires, those currently receiving CBT, other psychotherapy or secondary care for depression, or those who had received CBT in the past 3 years.

Mean duration of the CBT intervention was 6.3 months. Adding CBT to usual care significantly increased the treatment response compared with usual care alone at 6 months (response 46% with CBT plus usual care vs 22% with usual care alone; adjusted OR 3.26, 95% CI 2.10 to 5.06; p<0.001). Further adjusting these results for imbalances at baseline were reported to have a little effect (data not shown). Adding CBT to usual care also significantly increased the treatment response compared with usual care alone at 12 months (response 55% with CBT plus usual care vs 31% with usual care alone; adjusted OR 2.89, 95% CI 2.03 to 4.10; p<0.001; repeated measures analysis).

Adding CBT to the usual care in people in primary care whose depression has not responded to antidepressants is effective at increasing treatment response for up to 1 year.

Wiles N, Thomas L, Abel A, et al. Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial.Lancet 2013; 381:375–84.

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Kommentarer till inlägget

Kommentar från Alexander Larsson
26 augusti, 2014 kl 26 augusti 2014 (16:51)

Tack, jag håller med: KBT är väldigt bra i många sammanhang, bra att ha en studie som vetenskapligt underlag i samband med detta.

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